Structural Studies on Bacterial Proteins.
A dissertation presented for examination for the degree of Doctor of Philosophy.Cambridge, Pembroke College, 1960 Stock Code: 114798
NotesThe doctoral dissertation of prominent biochemist Richard Penry Ambler. From the library of his supervisor Frederick Sanger, with a large number of Sanger's pencilled annotations, largely Xs to mark specific points, as well as a few small corrections and short notes about the content.
Ambler obtained his doctoral degree under Sanger at Cambridge during the late 1950s and early 60s before joining the newly established department of molecular chemistry at the University of Edinburgh. "Ambler's research career was devoted to answering questions concerning the evolution of bacteria with the aid of amino acid sequence information. This led him to perfect protein sequencing techniques and in 1963 he published the first amino acid sequence of a bacterial protein, that of Pseudomonas cytochrome c551" (Scotsman obituary). His most significant work investigated the evolution of antibacterial resistance and cellular structures such as mitochondria (the powerhouse of the cell) and cytochromes (ancient proteins key to cellular energy production). Crucially, Ambler demonstrated that bacteria evolve in two ways, through the normal process of passing on mutations to their progeny, and also "horizontally", by absorbing and incorporating genetic material from other bacteria and organisms in their environment. "Such 'horizontal' gene transfer, he found, occurred with great frequency during the development of antibiotic resistance a discovery which has proved central to the understanding of what is now recognised as a major public health challenge" (Telegraph obituary).
Tall quarto. Original dark blue cloth, spine lettered in gilt. Typescript, text on the rectos only.
29 plates, some of which are full-page and others tipped-in, also tipped-in is a two-leaf offprint from <em>Nature</em> titled in typescript Appendix I, tables in the text.
Some spots and dampstain to cloth, lower corner bumped, dampstain also affecting pastedowns and top edge of portions of contents, some toning and spotting of contents, which are a little curled at the corners, a very good copy.
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